Due to aging and poor diet, many people have low levels of SAM-e, an important molecule that supports healthy moods and joints. Nature Made Mood Plus SAM-e is a dietary supplement that naturally restores your body’s SAM-e levels, helping you to balance emotions. These tablets are free of gluten and yeast and begin restoring your mood between 7-14 days when taken everyday.Manufactured to the highest standards of potency and purity.